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Internacional - América De Cali 6:15pm
Inter leads Group E on goal differential over fellow Brazilians Grêmio. They also lead the Brasileiro by two points through ten matches. Veteran attacker Thiago Galhardo is leading the league with eight goals. América comes into the match after a disappointing capitulation in the Colombian Superliga, losing the trophy to Junior after a 2-0 loss in the second leg at home. They return to league play this weekend.
Estudiantes Mérida - Alianza Lima 6:15pm
Los Académicos from Venezuela have not played since the pandemic outbreak and will struggle for match fitness against Alianza Lima. They come into the match after their first loss since the restart of the top flight in Peru in six matches. Goals have been hard to come by for Alianza, they'll be looking to leading scorer Joazinho Arroé to find the back of the net in Venezuela.
Independiente Medellín - Caracas FC 8:30pm
Neither team has returned to league play yet, so this could be a strange match as both teams try to find some consistency. Neither has won a match yet in this edition of the Libertadores, so both will be desperate to add some points in the table. Caracas did manage a draw with Boca Juniors back in March as Boca was fighting to win the league title in Argentina. Universidad Católica - Grêmio
Grêmio is level with Inter at the top of Group E and comes in unbeaten in their last three matches. However, they have also had a red card in each of their last three matches. El Trencito Azul is in 4th place in Ecuador right now and come in after a loss to Barcelona. However, that loss ended a 4-game winning streak that saw the side score 12 goals. Juan Manuel Tévez leads the team with five goals this season.
Bolívar - Palmeiras
Palmeiras has not lost since their first match back in the restart of play on July 22. They have had quite a few draws mixed in and are not scoring a ton of goals, but they have proven to be a tough team to beat. It could be a big ask for Bolívar, who are playing their first match since March.